Histamine

The final neurotransmitter upon which we will focus here is histamine. Like serotonin and the catechola-mines, histamine is a biologically active amine derived from amino acid precursors. It is formed by the decarboxylation of the amino acid histidine and is degraded via methylation to type B monoamine oxidase. Histamine, although heavily involved in the regulation of allergic and inflammatory reactions, has been found to be a neurotransmitter that is involved in a wide variety of behavioral processes. It is involved in the regulation of ingestive behavior (eating and drinking), sleep and arousal, sexual behavior, pain tolerance, learning and memory, and blood pressure.

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