Adjuvant Medical Treatment

In addition to neurotoxic effects of primary cancer therapy, adjuvant medications may also cause neuro-cognitive symptoms, complicating the assessment of patients who are on multiple medications. Drugs with cognitive and mood effects include steroids, pain medications, psychotropic medications, and antie-metics. Immunosuppressive agents, such as cyclospor-ine, are widely used in bone marrow transplantation and may also cause adverse CNS effects. Neurotoxi-city due to cyclosporine and other immunosuppressive agents may not always be reversible and can cause observable anatomic brain injury.



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