Epilepsy

The 1-year prevalence of epilepsy in the population is approximately 0.5%, the prevalence of migraine in persons with epilepsy ranges from 8 to 15%, and the prevalence of epilepsy in migraine patients is approximately 5.9%. Ottman and Lipton explored the co-morbidity of migraine and epilepsy based on the assumption that migraine and epilepsy share a common genetic basis. These investigators found that the incidence of migraine is 2.4 times higher in persons with epilepsy than in persons without epilepsy. The risk of migraine was not associated with the age of onset of epilepsy but was elevated in every subgroup of epilepsy defined by seizure type (higher risk for partial versus generalized onset seizures), etiology of epilepsy (higher risk for epilepsy caused by head trauma than idiopathic epilepsy), or family history of epilepsy. The risk of migraine was elevated both before and after seizure onset, indicating that migraine is not solely the cause or consequence of epilepsy. Genetic and environmental risk factors probably play an important role in the development of migraine and epilepsy, both of which share an alteration in neuronal excitability.

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

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