General Comments

Although nociceptive afferents are not a uniform or homogeneous population, certain general conclusions emerge. First, they transmit via small-diameter, slowly conducting axons. Second, they tend to transmit information about more than a single modality. Third, the spectrum of stimuli that activate these nociceptive afferents is remarkably similar from tissue to tissue. Finally, as was only touched upon in the foregoing brief description, the properties of these receptors are not static; they can be influenced by the state of their termination site and by preceding activity.

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