Long Term Potentiation Is a Form of Synaptic Plasticity That May Be Involved in Information Processing

As addressed earlier, Hebb increased our understanding of how information processing occurs in neurons by suggesting that activity in groups of neurons mediates memory formation. Because neurons communicate with each other only at synapses, changes in activity of groups of neurons likely occur at the synapses, and therefore memories are stored through LTP. The NMDA receptor is involved in forming LTP. Activation of the NMDA receptor requires both the release of the neurotransmitter glutamate and stimulation of the postsynaptic cell. That is, the

NMDA receptor must be activated by glutamate and simultaneously there must be sufficient depolarization of the postsynaptic membrane to relieve a magnesium block in the NMDA-associated ion channel, which allows entry of the ion calcium (Ca2+) into the postsynaptic terminal. Ca2+ activates a number of changes in the cells. Thus, this receptor acts as a coincidence detector, informing the neuron that it was activated in rapid succession. This is an example of a cellular mechanism that may be involved in information processing.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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