Gliomatosis Cerebri

This rare neoplasm has the greatest selectivity for the cerebral white matter of any brain tumor. Patients with this lesion present with personality changes, cognitive decline, focal neurologic signs, and seizures, and they are found to have diffuse neoplastic invasion of the white matter on neuroimaging studies. The origin of the tumor is debated because neuropathologic study has not identified any characteristic histopathology. Due to the high malignancy of this tumor, the prognosis is poor.

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