There are five types of dopamine receptors, all of which are metabotropic. Dopaminergic neurons are abundant in the substantia nigra and the ventral tegmental area; dopamine cells project to the basal ganglia, hypothalamus, and the limbic system to regulate voluntary movement, thinking, and planning. Dopamine plays an important role in the reward system and in addiction.
b. Norepinephrine NE is produced by the introduction of a hydroxyl group into the carbon chain of dopamine by dopamine b-hydroxylase.
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