NE is present in neurons of the locus ceruleus, which have widespread projections to the cerebral cortex, cerebellum, and spinal cord. NE is the transmitter used by the postganglionic neurons of the sympathetic nervous system.
c. Epinephrine In the adrenal medulla, NE is converted to epinephrine by methylation. This reaction is catalyzed by phentolamine-N-methyltransfer-ase and requires S-adenosylmethionine as a methyl donor.
a. Dopamine For the synthesis of catecholamines, the essential amino acid L-tyrosine is converted to l-dihydrophenylalanine (l-DOPA).
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