Corpus Callosum Labeled

The corpus callosum is composed of millions of nerve fibers that connect the two halves of the brain. These fibers traveling together from one cerebral hemisphere to the other form a brain structure easily visible to the beginning student of neuroanatomy. Figure 1 shows a saggital section of the brain, which is a slice that runs from front to back on a vertical plane. This slice passes through the midline. The large curved structure in the middle of the brain is the corpus callosum.

Although there is considerable variability in the size and shape of the corpus callosum in humans, it is known that it contains approximately 200 million fibers that carry neural signals from one side of the brain to the other. Although most of these fibers are thought to be excitatory, their effect may be inhibitory due to the activity of inhibitory interneurons. Approximately half of these fibers are small and unmye-linated. These fibers transmit information more slowly than the larger myelinated axons, which are capable of extremely rapid transmission of information. Some of the fibers connect to similar areas in the right and left hemispheres; other fibers go to areas in the contralateral hemisphere that are analogous to areas that have dense ipsilateral connections with their area of origin. A final group of fibers are diffusely connected to the contralateral hemisphere. If there is an analogy in the human brain with findings reported in the animal literature, some neurons may cross the callosum and descend to the subcortical structures before terminating.

Fibers from different areas of the cortex cross the callosum in discrete locations. To understand this phenomenon, it is necessary to examine the divisions of

Corpus Callosum And Cerebral Cortex
Figure 1 Sagittal section of the brain with major divisions of the corpus callosum labeled.

the corpus callosum (Fig. 1). The most anterior part of the callosum is the rostrum. Just behind the rostrum, the callosum bends to form the genu (or knee) and then extends posteriorly in the body. The body constricts slightly to become the isthmus and finally terminates in the slightly bulbous splenium. There is a great deal of individual variation in the shape and thickness of the different parts of the callosum. There have been attempts to understand differences in the anatomy of the right and left hemispheres and in the lateralization of function with regard to the morphology of the corpus callosum. As behavioral claims regarding the contributions of different areas of the callosum become more precise, it will become more crucial to be able to carefully define the areas of the callosum in which particular fibers cross. Currently, however, the areas are conventionally defined as proportions of the length of the callosum. There seems to be minimal difference whether the curvature of the callosum is taken into account or simply maximum anterior and posterior extension is used for the partition. The anterior one-fourth of the callosum is considered the genu. The rostral body begins directly behind the genu, extending back to include the anterior one-third of the callosum. The center one-third of the callosum is split into two equal sections, the anterior and posterior midbody. The isthmus extends from the posterior one-third to the posterior one-fifth of the callosum. Finally, the most posterior one-fifth is considered the splenium.

Because these definitions are arbitrary, they may differ in detail from investigator to investigator, depending on the investigator's emphasis.

Generally, however, it is believed that the fibers that pass through the different regions of the corpus callosum represent the anterior-to-posterior organization of the cerebral cortex (Fig. 2). Deepak Pandya and Benjamin Seltzer demonstrated an anterior-to-posterior organization of the callosal fibers of passage in the rhesus monkey. Prefrontal cortex and premotor cortex axons cross in the rostrum and genu. Motor and somatosensory axons are found primarily in the body. Auditory and association areas are represented in the isthmus and visual areas in the splenium. Stephen Lomber and colleagues document a similar arrangement in the corpus callosum of the cat, although auditory fibers are found throughout the body and dorsal splenium, largely overlapping with limbic and visual fibers except in the very ventral sections of the splenium, which are entirely visual. The same anterior-to-posterior organization has been demonstrated by Marie Christine de Lacoste and colleagues in the

Somatosensory Cortex Topography

Figure 2 Areas of the cortex where fibers of the corpus callosum originate are coded to match the section of the corpus callosum where those fibers cross to the other hemisphere (adapted from M. C. DeLacoste, J. B. Kirkpatrick, and A. D. Ross, Topography of the human corpus callosum, J. Neuropathol. Exp. Neurol. 44, 578-591, 1985).

Figure 2 Areas of the cortex where fibers of the corpus callosum originate are coded to match the section of the corpus callosum where those fibers cross to the other hemisphere (adapted from M. C. DeLacoste, J. B. Kirkpatrick, and A. D. Ross, Topography of the human corpus callosum, J. Neuropathol. Exp. Neurol. 44, 578-591, 1985).

human brain. That is, the right and left prefrontal, orbital-frontal, and frontal language areas are connected in the rostrum and the genu. The anterior part of the body carries fibers from the sensory and motor regions that abut the central sulcus. It appears that fibers from the area around the Sylvian fissure, associated with language function in the left hemisphere, cross in the posterior part of the body or isthmus. Finally, the splenium carries fibers connecting the visual areas of the occipital lobe.

Although it is now known that there are distinctive behavioral deficits associated with lesions to some regions of the callosum, contributions of the corpus callosum to behavior have not been easy to observe and understand. Some scientists have argued that evolutionary evidence suggests that the corpus callo-sum plays a distinctive role in human behavior. The callosum is not present in some primitive marsupials and takes on greatly increased prominence in the human species. The prominence of the corpus callo-sum appears to increase as lateralization increases, but this relationship is currently very speculative. In fact, James Rilling and Thomas Insel argue that, based on studies of 11 primate species, only the size of the splenium increases in proportion to increasing brain size, whereas the size of the corpus callosum as well as that of the anterior commissure are actually reduced relative to the size of other structures in higher primates. This observation suggests that any changes in the callosum related to human evolution are specific to particular areas of the callosum such as the splenium.

Developmentally, the callosum is a small structure in the neonatal brain that increases in size and prominence as the fibers myelinate (Fig. 3). At approximately 7 weeks of gestation, the lamina terminalis begins to thicken forming the commissural plate. By approximately 9 weeks cells begin to form the massa commissurelis, which supports the growth of the first commissural fibers at approximately 12 weeks. The basic structure of the callosum is present by 20 weeks and it continues to thicken and develop until birth, with development of the genu and body occurring before that of the splenium and rostrum. The myelinization of the corpus callosum is not believed to be complete until puberty, and recent evidence suggests that it reaches its maximum size at approximately age 25. It has been argued that the distinctive evolutionary and developmental patterns suggest a special role for the callosum in human behavior. Sandra Witelson has argued strongly that the anatomy of the callosum may be key to

Cor[ Callosum Labelled

1 cm

■ Anterior commissure □ Corpus callosum

Corpus Callosum Human Brain
Figure 3 Relative size of the corpus callosum is seen in at 16 weeks (A), 40 weeks (B), and at adulthood (C) (adapted from S. P. Springer and G. Deutsch, Left Brain, Right Brain: Perspectives from Cognitive Neuroscience. p. 260. Freeman, New York, 1997).

understanding developmental issues of lateralization and hemispheric specialization. Deliniating that role has proven difficult.

Was this article helpful?

0 0
Unraveling Alzheimers Disease

Unraveling Alzheimers Disease

I leave absolutely nothing out! Everything that I learned about Alzheimer’s I share with you. This is the most comprehensive report on Alzheimer’s you will ever read. No stone is left unturned in this comprehensive report.

Get My Free Ebook

Post a comment