Sfq

Epinephrine

Only a few neurons in the central nervous system use epinephrine. These are located together with noradre-nergic cells in the medulla oblongata, solitary tract nucleus, and medial longitudinal fascicle.

As we have seen, the synthesis of epinephrine is carried out in four enzymatic steps, the first two being common to dopamine, NE, and epinephrine, the first three being common to NE, and epinephrine, and the last needed only for the synthesis of epinephrine. Why are NE and epinephrine not made in dopaminergic neurons? The particular neurotrans-mitter produced is determined by the absence of the next enzyme. Thus, no products past dopamine are produced in dopaminergic neurons because dopa-mine b-hydroxylase is absent. Similarly, epinephrine is not produced in neurons that lack the methyl-transferase.

d. Serotonin (5-HT), an Indoleamine The essential amino acid L-tryptophan is oxidized to 5-hydroxy-tryptophan (5-HTP) by tryptophan hydroxylase, an enzyme homologous to tyrosine hydroxylase. The amino acid decarboxylase that operates in the cate-cholamine pathway also decarboxylates 5-HTP to serotonin.

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