Gaba Production And Degradation

GABA is unique among neurotransmitters because it can be synthesized by either of two closely related enzymes. Almost all GABA derives from the decar-boxylation of glutamate, catalyzed by glutamic acid decarboxylase [glutamate decarboxylase (GAD); l-glutamate 1-carboxylase, E.C. 4.1.1.15]. Pyridoxal phosphate [PLP; derived from pyridoxine (vitamin B6)] is an obligate cofactor for GAD, as it is for many other decarboxylases. GABA can also be synthesized from ornithine via ornithine decarboxylase, although this is a minor route of synthesis. The GABA-synthesizing pathway is illustrated in Fig. 2.

Understanding And Treating Autism

Understanding And Treating Autism

Whenever a doctor informs the parents that their child is suffering with Autism, the first & foremost question that is thrown over him is - How did it happen? How did my child get this disease? Well, there is no definite answer to what are the exact causes of Autism.

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