Gaba Production And Degradation

GABA is unique among neurotransmitters because it can be synthesized by either of two closely related enzymes. Almost all GABA derives from the decar-boxylation of glutamate, catalyzed by glutamic acid decarboxylase [glutamate decarboxylase (GAD); l-glutamate 1-carboxylase, E.C. 4.1.1.15]. Pyridoxal phosphate [PLP; derived from pyridoxine (vitamin B6)] is an obligate cofactor for GAD, as it is for many other decarboxylases. GABA can also be synthesized from ornithine via ornithine decarboxylase, although this is a minor route of synthesis. The GABA-synthesizing pathway is illustrated in Fig. 2.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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