Neurologic Disorders

Disorders of the cerebral white matter comprise a widely diverse group of neuropathologic conditions. Many of these disorders are well-known in neurology, but others have been recently discovered with the use of MRI, and the number of entries on this list is likely to continue growing. This section reviews the cerebral white matter disorders using a classification system based on known or presumed etiology. Major categories are presented with the disclaimer that some diseases have an unknown etiology and are included in the category that is most appropriate given this uncertainty. Individual disorders are included if there is sufficient neuropathologic or neuroimaging evidence indicating that the cerebral white matter is involved. The intent is to provide an organizational framework for considering these disorders; exhaustive discussions can be found in standard textbooks of neurology.

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