Huntingtons Disease

The rationale for intrastriatal grafting in HD patients in many ways is similar to that for, PD but the methodological challenges could be greater due to the more complex neurophysiological substrate. Nevertheless, extensive efforts are under way to establish a series of large-scale clinical trials, and the preliminary data are currently under evaluation. More promising are the studies analyzing the benefits of cell grafts in primate models of HD. Like in PD, much hope is invested in developing neuronal cells that can be manipulated in vitro to promote their in vivo functional integration into the degenerating striatum of HD patients.

Based on successful animal models, human trials of striatal transplantation for the treatment of Hunting-ton's disease have been initiated. The first human transplant for Huntington's disease was performed in 1990 in Mexico using an open surgical procedure. Follow-up of this patient and a second treated by the same group showed slowed progression of the disease. Clinical studies have also been initiated in the United States. Twelve-month follow-up showed increased striatal tissue volume by MRI and improved measures of mobility and cognition. Hopefully, as human trials for the treatment of Huntington's disease progress, large, organized, and controlled studies will emerge that will effectively evaluate this treatment modality.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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