Ischemic Stroke A Background and Pathogenesis

Ischemia is defined as a reduction in blood flow. Progressive ischemia first disrupts neuronal functioning and later threatens cell viability. Although varia bility in normal CBF exists, levels below approximately 20 ml/100 g/min result in electrophysiological and functional deficits. CBF levels below 10 ml/100 g/min result in disruption of membrane integrity and cellular death (as seen within an area of completed infarction). Intermediate levels of CBF (between 10 and 20 ml/100 g/min) are seen within the ischemic penumbra, the area of potentially viable tissue immediately surrounding the infarction. Salvaging the potentially amenable ischemic penumbra remains an area of intense research.

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