Opioid Receptors

The opioid receptors were first demonstrated in 1973 with the binding of radiolabeled opiates to brain membranes. To date, three distinct families of opioid receptors have been identified that share many features. On the molecular level, they all are members of the G protein-coupled receptor family, which is a large family of receptors located within membranes. Members of this receptor family span the membrane seven times, providing both intracellular and extracellular domains (Fig. 3). The opioids and opioid peptides bind to the extracellular component of the receptor and activate G proteins inside the cell. The opioid receptors are almost exclusively coupled to inhibitory systems, primarily Go and G;. Each receptor is encoded by a separate gene, but there is high homology between them.

All About Alzheimers

All About Alzheimers

The comprehensive new ebook All About Alzheimers puts everything into perspective. Youll gain insight and awareness into the disease. Learn how to maintain the patients emotional health. Discover tactics you can use to deal with constant life changes. Find out how counselors can help, and when they should intervene. Learn safety precautions that can protect you, your family and your loved one. All About Alzheimers will truly empower you.

Get My Free Ebook


Post a comment