Induction of Barrier Properties in Capillary Walls

Blood-brain barrier properties are encouraged by cells in the developing brain. Fenestrations and loose association of endothelial cells are obtained when the CNS is vascularized, but these properties are unsuited to CNS homeostasis. Thus, the windows shortly disappear and tight junctions begin to form. In tissue culture, these refinements are shown to require the presence and influence of brain tissue. The cells exerting these influences could be neurons, oligoden-drocytes, or astrocytes, perhaps two of these, or all of the above. Through their processes and end feet upon the outer surface of blood vessels, astrocytes in some way appear to induce, along with other cells of the CNS, capillary endothelial barrier properties.

Together with cAMP agonists, they increase the interdigitation and total area of endothelial cell tight junctions.



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