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Figure 3 Simulated responses to voltage-clamp stimuli. Simulated Na+ (a) and K+ (b) in response to voltage-clamp steps from a holding potential of—90 mV to clamp potentials of—80 (solid lines), —40 (dashed lines), 0 (dotted llines), and 40 mV (dashed and dotted lines). The Na + flux is inward (negative) and is characterized by rapid activation and slower inactivation. The K+ flux is outward (positive) and activates significantly more slowly than the Na+ flux.

Figure 3 Simulated responses to voltage-clamp stimuli. Simulated Na+ (a) and K+ (b) in response to voltage-clamp steps from a holding potential of—90 mV to clamp potentials of—80 (solid lines), —40 (dashed lines), 0 (dotted llines), and 40 mV (dashed and dotted lines). The Na + flux is inward (negative) and is characterized by rapid activation and slower inactivation. The K+ flux is outward (positive) and activates significantly more slowly than the Na+ flux.

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