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"Blockade of voltage-gated sodium channels. ^Potentiation of GABAergic mechanisms. "Blockade of glutamatergic mechanisms. ^Blockade of thalamic calcium channels.

"Blockade of voltage-gated sodium channels. ^Potentiation of GABAergic mechanisms. "Blockade of glutamatergic mechanisms. ^Blockade of thalamic calcium channels.

In the common idiopathic generalized epilepsies, positional cloning of susceptibility genes was less successful due to the underlying complex genetic disposition. Many chromosomal regions (on chromosomes 6 and 15) are thought to harbor susceptibility genes for generalized seizures associated with juvenile myoclonic epilepsy.

In the genetic counseling of patients with epilepsies with complex modes of inheritance, empirical risk estimates are used. The recurrence risk for the offspring of probands with idiopathic generalized epilepsies is on the order of 5-10%.

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