Lee J Martin

Johns Hopkins University School of Medicine

I. Introduction

II. Alzheimer's Disease Is a Progressive Neurodegenerative Disease of Elderly Individuals That Causes Synapse Defects and Dementia

III. ALS Is a Disease of Motor Neurons

IV. Neurodegenerative Diseases of the Basal Ganglia Cause Movement Disorders

V. Neuronal Death Occurs in Different Forms

VI. Programmed Cell Death Occurs Normally during Nervous System Development

VII. Glutamate Receptor Excitotoxicity Kills Neurons

VIII. Neuronal Degeneration Can Occur as an Apoptosis-Necrosis Continuum

IX. Apoptosis May Have Important Contributions to Neurodegenerative Disorders in Humans

X. Animal Models of Neurodegeneration Are Necessary to Understand How Neurons Die

XI. The Future Is Promising for Understanding the Causes of Neurodegenerative Disorders in Humans and Identifying Treatments

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