After observing that lithium produced placidity in guinea pigs, in 1949 Cade suggested that this compound could possess antiexcitement properties in humans. Although lithium was introduced as a treatment for acute mania, the antimanic effect is maximal after 7-10 days, thus, faster acting agents such as neuroleptics are often used in conjunction with lithium. Lithium has been shown to provide effective prophylaxis for BP disorder. Bipolar lithium-treated patients have a risk of relapse of 34-36% compared to more than 79% in comparable patients given placebo. Lithium has a narrow therapeutic index, however, and high levels can produce seizures, coma, and eventually death. Even when it is present in its therapeutic concentration range of 0.8-1.2 mEq/liter, patients treated with lithium can have gastrointestinal side effects, such as vomiting and/or diarrhea, endocrine side effects, such as inhibition of thyroid function, renal side effects, such as polyuria with polydipsia, and CNS side effects, such as drowsiness, memory deficits, and tremors.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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