After observing that lithium produced placidity in guinea pigs, in 1949 Cade suggested that this compound could possess antiexcitement properties in humans. Although lithium was introduced as a treatment for acute mania, the antimanic effect is maximal after 7-10 days, thus, faster acting agents such as neuroleptics are often used in conjunction with lithium. Lithium has been shown to provide effective prophylaxis for BP disorder. Bipolar lithium-treated patients have a risk of relapse of 34-36% compared to more than 79% in comparable patients given placebo. Lithium has a narrow therapeutic index, however, and high levels can produce seizures, coma, and eventually death. Even when it is present in its therapeutic concentration range of 0.8-1.2 mEq/liter, patients treated with lithium can have gastrointestinal side effects, such as vomiting and/or diarrhea, endocrine side effects, such as inhibition of thyroid function, renal side effects, such as polyuria with polydipsia, and CNS side effects, such as drowsiness, memory deficits, and tremors.

Do Not Panic

Do Not Panic

This guide Don't Panic has tips and additional information on what you should do when you are experiencing an anxiety or panic attack. With so much going on in the world today with taking care of your family, working full time, dealing with office politics and other things, you could experience a serious meltdown. All of these things could at one point cause you to stress out and snap.

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