O Hyperthermia

The pathophysiology of this rare cause of cerebral edema is poorly understood. Although the fatal consequences of heat stroke have been recognized since ancient times, the underlying mechanisms await clarification. Scant pathologic material suggests a combination of cytotoxic and vasogenic components, secondary to an increase in BBB permeability due to the release of multiple chemical factors and direct cytotoxic damage. Age and physiologic state of the individual appear to be important determinants of clinical outcome in hyperthermic injury.

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