O2

Figure 3 Schematic illustration of how astrocytic glycogen appears to fuel axons in the absence of glucose. Blood glucose first encounters astrocytic end feet as it is transported into the brain. In the absence of glucose, astrocytic glycogen is broken down into lactate, which is transported to the extracellular space via a monocarboxylate transporter (MCT). It is then taken up by a MCT in axons and is oxidatively metabolized to produce the energy needed to sustain excitability. LDH5 preferentially reduces pyruvate to lactate, whereas LDH1 preferentially oxidizes lactate to pyruvate. This scheme recognizes that astrocytes can subsist, at least transiently, on glycolytic energy metabolism, whereas axons require oxidative metabolism.

\LDH 1 Pyruvate

All About Alzheimers

All About Alzheimers

The comprehensive new ebook All About Alzheimers puts everything into perspective. Youll gain insight and awareness into the disease. Learn how to maintain the patients emotional health. Discover tactics you can use to deal with constant life changes. Find out how counselors can help, and when they should intervene. Learn safety precautions that can protect you, your family and your loved one. All About Alzheimers will truly empower you.

Get My Free Ebook


Post a comment