Progressive Multifocal Leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the cerebral white matter that frequently appears in patients with AIDS. The infectious agent is a member of the papavovirus family known as the JC virus. The virus infects oligodendro-cytes, and demyelination is seen pathologically. Multi-focal nonenhancing white matter involvement is typically seen on MRI scanning. The course of PML is invariably progressive, and attempts to treat the disease pharmacologically have been disappointing.

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All About Alzheimers

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