The cerebral white matter constitutes approximately onehalf

the volume of the human brain. White matter establishes anatomic connectivity between cortical and subcortical gray matter regions within and between the hemispheres, and it enables more efficient neuronal transmission and cerebral function. Disorders of the cerebral white matter comprise a diverse group of neuropathologic conditions, of which multiple sclerosis is the best known. Neurologic dysfunction is well-known to be associated with these disorders, and neurobehavioral syndromes including dementia are also being increasingly recognized. Recognition of these clinical phenomena represents an opportunity to improve the care of individuals with these disorders and to expand our understanding of the human brain.

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