Behavioral syndromes following exposure to neuro-toxic chemicals must be differentiated from other neurological disorders. This is only accomplished with careful analysis of the time line relationship between reported exposure conditions and the emergence of symptoms. Markers of exposure such as air or water samples and biological specimens also should be obtained whenever possible to support the diagnosis. Clinical findings and/or corraborative diagnostic test data are of value when these results are interpreted in the context of developmental, academic, and social history, medical and psychiatric history, information gleaned from interviewing the patient and/or significant others, the patient's behavior in the test situation, and qualitative findings observed in the test material. Follow-up testing is useful in documenting prognosis, confirming the effect of exposure to neurotoxic chemicals, and that a neurodegenerative process is not responsible for the individual's symptoms and signs of neurologic disfunction.

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