Epidemiology Of Neurocognitive Complications

Neurocognitive complications become more prevalent with progression of HIV disease. Thus, HIV dementia almost never occurs in stages A and B of HIV disease, but it may be found in 4-7% of those with frank AIDS. In earlier stage disease, neurocognitive impairment, if it is seen, is typically mild and may have a relapsing-remitting course. Observers continue to disagree on the prevalence of these complications in earlier stage disease. Data from the San Diego HIV Neurobeha-vioral Research Center are presented in Fig. 6. It can be seen that the rate of impairment increases with stage of disease. In the medically asymptomatic form of disease, only the mildest form of neurocognitive impairment tends to be observed (i.e., asymptomatic neuropsychological impairment). Minor cognitive motor disorder becomes more prevalent in stage B and stage C disease.

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