Gaba Function

The GADs differ in their PLP dependence, encoding gene, membrane association, and subcellular location, which suggests that the GADs may synthesize separate pools of GABA that serve different functions. Although GABA is a neurotransmitter, it also functions as a developmental molecule and can contribute to the tricarboxylic acid cycle to provide energy to the cell. Studies of GABA in transgenic mice deficient in one GAD support the hypothesis that GAD65-synthesized GABA is predominantly packaged for neurotransmission, whereas GAD67-synthesized GABA remains in the cytosol and is available for alternate functions.



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