Genetics

Genetic factors play a major role in the etiology of idiopathic epilepsies. Progress in molecular genetics has revealed several susceptibility loci and causative gene mutations in many rare human epilepsies with monogenic inheritance, such as the progressive myo-clonus epilepsies. Mutations in the gene encoding the a4 subunit of the neuronal nicotinic acetylcholine receptor gene have been identified as predisposing to autosomal-dominant nocturnal frontal lobe epilepsy. Mutations of two genes encoding potassium channels cause benign neonatal familial convulsions. A gene encoding the b subunit of the voltage-gated sodium channel has been identified in a rare syndrome called generalized epilepsy with febrile seizures plus. These findings suggest that at least some epilepsies are related to ion channel dysfunction.

Table III

Mode of Action of Old and New Antiepileptic Drugs

Table III

Mode of Action of Old and New Antiepileptic Drugs

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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