Genetics

Genetic factors play a major role in the etiology of idiopathic epilepsies. Progress in molecular genetics has revealed several susceptibility loci and causative gene mutations in many rare human epilepsies with monogenic inheritance, such as the progressive myo-clonus epilepsies. Mutations in the gene encoding the a4 subunit of the neuronal nicotinic acetylcholine receptor gene have been identified as predisposing to autosomal-dominant nocturnal frontal lobe epilepsy. Mutations of two genes encoding potassium channels cause benign neonatal familial convulsions. A gene encoding the b subunit of the voltage-gated sodium channel has been identified in a rare syndrome called generalized epilepsy with febrile seizures plus. These findings suggest that at least some epilepsies are related to ion channel dysfunction.

Table III

Mode of Action of Old and New Antiepileptic Drugs

Table III

Mode of Action of Old and New Antiepileptic Drugs

Do Not Panic

Do Not Panic

This guide Don't Panic has tips and additional information on what you should do when you are experiencing an anxiety or panic attack. With so much going on in the world today with taking care of your family, working full time, dealing with office politics and other things, you could experience a serious meltdown. All of these things could at one point cause you to stress out and snap.

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