The Role Of Microglia In Cns Autoimmunity And Inflammation

Microglia exert multiple functions in CNS autoimmu-nity and inflammation. Microglia can present antigens to T cells, produce cytokines and toxic radicals, and exert effector functions in CNS inflammation. Micro-glia are very sensitive to systemic stimuli. Intraperito-neal injections of the nonspecific immune activator

LPS led to increased IL-12 expression in parenchymal microglia and cyclooxygenase-2 activity in perivascu-lar microglia. Moreover, microglia proliferated in response to circulating cytokines as shown for IFN-g.

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