Programmed Cell Death Occurs Normally During Nervous System Development

Naturally occurring apoptotic degeneration of neurons occurs normally in the developing nervous system (Fig. 10). Animals are born with excess numbers of

Table VI

Molecular Regulation of Programmed Cell Death

Bcl-2 family

Antiapoptotic proteins Proapoptotic proteins Caspase family IAP family Tumor suppressor

Bcl-2 family

Antiapoptotic proteins Proapoptotic proteins Caspase family IAP family Tumor suppressor

family

Bcl-2a

Bax"

Apoptosis "initiators:" caspase-2, -8, -9, -10

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