It is known that the pancreatic islets are innervated by the autonomic nerves. The net effects of activation of the nerves on islet hormone secretion, the presumed neurotransmitters mediating these effects, and the putative receptors and their signaling pathways have also been established. In particular, several neuropep-tides have been localized to islet nerve terminals, and their actions on islet hormone secretion have been documented under a variety of experimental conditions. Studies are now required to establish the physiology and pathophysiology of the islet nerves and their neurotransmitters, particularly concerning the possible involvement of the nerves in the patho-physiology of glucose intolerance, type 2 diabetes, and obesity.
See Also the Following Articles
HOMEOSTATIC MECHANISMS • NEUROTRANSMITTERS • NOREPINEPHRINE • PEPTIDES, HORMONES, AND THE BRAIN AND SPINAL CORD
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