Synaptic Organization Of The Nervous System

This subject lies at the heart of the organization of the human or any other nervous system. A synapse, by definition, includes presynaptic and postsynaptic membranes separated by a narrow cleft about 1220 nm across. As noted, EM demonstration of this cleft provided definitive proof of the anatomical tenet of the neuron doctrine: nerve cells are separate. The cells that face each other across this cleft may be two neurons, a neuron and a skeletal or smooth muscle fiber, or a neuron and a gland cell (usually a smooth muscle fiber in that gland).

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