African Swine Fever

Michael S Denyer and Philip J Wilkinson, Institute for Animal Health, Pirbright Laboratory, Pirbright, UK

African swine fever (ASF) is a highly contagious acute hemorrhagic disease of domestic pigs caused by a large icosahedral DNA virus which produces a wide range of clinical signs. Protective immunity can be stimulated in vivo but classical neutralizing antibodies have not been demonstrated. The complete genome has been sequenced and some proteins that could enable the virus to evade the host immune response have been identified. There is no vaccine.

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