Uterine cervical carcinoma Alcoholic liver cirrhosis Neoplasias

Plasmacytoma and myeloma Lennert's T cell lymphoma Renal cell carcinoma Others

Mesangial proliferative glomerulonephritis samples from patients with PGN. Furthermore, a close relationship was observed between the level of urine IL-6 and the progression of PGN. These results suggest that deregulated IL-6 production in MC is involved in the pathogenesis of PGN. Other diseases related to the deregulated expression of IL-6 are summarized in Table 2.

IL-6 transgenic mice

Transgenic mice with the human IL-6 gene conjugated with the immunoglobulin enhancer have been produced. The Ep-IL-6 gene was expected to express IL-6 constitutivcly in B lineage cells. In all founder mice, a marked increase in serum IgGl and enlargement of spleen, thymus and lymph nodes were observed. All of the mice died within several months and the histology of lymph nodes showed a massive infiltration of plasma cells. However, Southern blot analysis of DNAs from lymph nodes or spleen did not show any monoclonal or oligoclonal rearrangements of the Ig heavy chain genes. Furthermore, plasma cells were not transplantable to syngeneic recipients. The other changes consistently observed in E|x-IL-6 transgenic mice were an increase in mature megakaryocytes in bone marrow and mesangial proliferative glomerulonephritis.

In IL-6 knockout mice approximately 80-90% reductions of antiviral antibody response and acute phase reaction have been observed, confirming that IL-6 is one of the essential factors for antibody production and the acute phase reaction.

See also: Acute phase proteins; B lymphocyte differentiation; Bone marrow and hematopoiesis; Cytokine assays; Cytokine genes, regulation of; Cytokines; Cytokine receptors; Granulocyte colony stimulating factor (G-CSF); Interleukin 3; Interleukin 6 receptor; T lymphocyte differentiation.

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