Anemia Autoimmune Hemolytic In Human

Alan D Schreiber, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA

Copyright © 1998 Elsevier Ltd. All Rights Reserved.

The autoimmune hemolytic anemias represent a group of disorders in which individuals produce antibodies directed toward one or more of their own erythrocyte membrane antigens. This in turn leads to destruction of the erythrocytes. An effective manner in which to approach autoimmune hemolytic anemia is to analyze which class of antibody is responsible for the hemolysis. In general, there are two major classes of antierythrocyte antibodies which produce hemolysis in humans: immunoglobulin G (IgG) and IgM. The pattern of red blood cell clearance, the site of organ sequestration, the response to therapy, and the prognosis all relate to the class of antierythrocyte antibody involved.

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