Figure 1 The DT390anti-CD3sFv construct. Left to right (N-ter-minus to C-terminus): truncated diphtheria toxin, ASGGPE connector, VL, flexible linker, and VH. Below is a diagram of the folded protein with a function monovalent binding site.

antitumor and anti-GVHD effects in in vivo animal models.

The future of IT conjugates for in vivo use will depend upon solving the toxic side-effects of these potent reagents without hindering their biological efficacy.

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