Biological effects of IL15

IL-15, like IL-2, is a growth factor for activated mouse and human T cells, activated, purified human B cells, and a subpopulation of human natural killer

(NK) cells. In addition, IL-15 synergizes with IL-12

to induce proliferation of resting mouse TH1 clones and CD4+ T cell blasts. IL-15 induces locomotion and migration of human T cells, but appears to have no chemokinetic or chemotactic activity on human monocytes, neutrophils or B cells. IL-15 stimulates cytokine production by NK cells, especially when used in combination with IL-12, and will also induce cytokine production by T cells. Human B cells stimulated with the combination of soluble CD40L and IL-15 secrete polyclonal immunoglobulin M (IgM), IgGl, and IgA, but not IgG4 or IgE.

IL-15 enhances cytotoxic activity of both T cells and NK cells. It induces alloantigen-specific cytotoxic T lymphocytes (CTLs) from human mixed leukocyte cultures and lymphokine-activated killer (LAK) activity from cultures of human PBMCs, large granular lymphocytes, or NK cells. IL-15 treatment induces protective antitumor responses in mouse tumor models that have been shown to be responsive to IL-2 therapy and in which antitumor activity involves either the induction of LAK activity or tumor-specific CTLs.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment