Biological effects of IL15

IL-15, like IL-2, is a growth factor for activated mouse and human T cells, activated, purified human B cells, and a subpopulation of human natural killer

(NK) cells. In addition, IL-15 synergizes with IL-12

to induce proliferation of resting mouse TH1 clones and CD4+ T cell blasts. IL-15 induces locomotion and migration of human T cells, but appears to have no chemokinetic or chemotactic activity on human monocytes, neutrophils or B cells. IL-15 stimulates cytokine production by NK cells, especially when used in combination with IL-12, and will also induce cytokine production by T cells. Human B cells stimulated with the combination of soluble CD40L and IL-15 secrete polyclonal immunoglobulin M (IgM), IgGl, and IgA, but not IgG4 or IgE.

IL-15 enhances cytotoxic activity of both T cells and NK cells. It induces alloantigen-specific cytotoxic T lymphocytes (CTLs) from human mixed leukocyte cultures and lymphokine-activated killer (LAK) activity from cultures of human PBMCs, large granular lymphocytes, or NK cells. IL-15 treatment induces protective antitumor responses in mouse tumor models that have been shown to be responsive to IL-2 therapy and in which antitumor activity involves either the induction of LAK activity or tumor-specific CTLs.

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