Blocking incomplete antibodies

Sometimes the Rh antibody cannot be detected, even at body temperature, in mothers who have had RhHDN babies. This is because the antibody, though present, is 'hidden'. When Rh-positive cells are suspended in the suspected serum, and anti-D (IgM) is added, the cells are not agglutinated (as would be expected). This is because the antigen sites have already been blocked with the mother's IgG blocking, or incomplete, anti-D. ('Blocking' is the term used by Wiener - it is synonymous with 'incomplete', as used by Race.)

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