Breaking anergy

B cells made anergic by chronic exposure to a self antigen are able to be activated in some instances. As indicated above, stimulation of anergic B cells through the CD40 molecule in the presence of IL-4 is able to induce proliferation and differentiation of the B cell. Similarly, extensive cross-linking of surface immunoglobulin on the B cell is able to activate the cell. This can be achieved, for example, when a B cell chronically exposed to soluble monomeric self antigen encounters the same antigen in a highly multimerized form such as a cell protein. In this case, the B cell will proliferate and differentiate into an antibody-forming cell in the presence of the appropriate cofactors. This reversal of anergy is dependent on the strength of the receptor signal. In the presence of soluble self antigen, anergic B cells are killed by antigen specific nontolerant helper T cells. This death is dependent on anergic B cells expressing the apoptosis-inducing molecule Fas and the helper T cells expressing its ligand. This lethal embrace can be transformed into a stimulatory one if the antigen receptor stimulation given to the B cell is sufficiently strong.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment