Bred for low mammary tumor incidence from a cross of a Bagg albino female and a DBA male (Strong, 1936). Genetic contamination is thought to account for the differences between substrains. Carries a Mus musculus domesticus origin Y chromosome (Tucker etal, 1992).

Infectious agents

Susceptible to: Theiler's virus (Rodriguez et al,

1990), measles virus (Neighbour et al, 1978), Ectro-melia virus strain C (Ermolaeva et al, 1972), Bacillus piliformis (Tyzzer's disease) (Waggie et al, 1981), Onchocerca lienalis microfilariae (Folkard et al, 1995), Mycobacterium lepraemurium (Roch et al,

1991), Schistosomia mansoni (Henderson et al, 1993).

Resistant to: murine herpesvirus (Kapoor et al,

1992), rabies virus (Lodmell et al, 1995); Salmonella typhimurium strain (Matsiota-Bernard et al, 1993), Neisseria gonorrhoeae (Johnson et al, 1989), Plasmodium berghei ANKA strain (Contreras et al, 1980), Streptococcus mutans-induced dental caries (Kurihara et al, 1991).

Immunological parameters

High gross tumor incidence (Storer, 1966; Smith et al, 1973). Susceptible to ozone toxicity (Goldstein et al, 1973) and streptozoin-induced renal epithelial tumors (Hard, 1985).

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