CD1 genes and CD1 protein structure

CD1 genes are MHC-unlinked, i.e. the human CD1 genes are encoded on chromosome 1, while HLA genes are encoded on chromosome 6. Similarly, the mouse CD1 genes are encoded on chromosome 3, whereas MHC genes are mapped to chromosome 17. The intron-exon structure of CD1 genes is similar to that of the MHC class I genes (Figure 1).

At least four human CD1 proteins (the CDla, b c and d isoforms) are expressed on the surface of cells in association with (32m. The protein products of these genes have been loosely classified into two groups according to their structure and tissue distribution (Table 1). The first group includes human CDla, CDlb and CDlc, which are abundantly expressed on professional antigen-presenting cells such as Langerhans cells, dermal and lymph node cells, dendritic cells, mantle zone B cells and cyto-kine-activated monocytes. The second group includes human CDld, and mouse CD1.1 and CD 1.1, which are strongly expressed on the intestinal epithelium.

Amino acid homology of CD1 proteins and MHC class I and II molecules is minimal in the cxl domain

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