Cd139

CD140a a-platelet-derived growth factor (PDGF) receptor

CD140b /3-platelet-derived growth factor (PDGF) receptor

B, M, G Undetectably expressed

Focal EC, stromal cell lines

CD141 Thrombomodulin

CD142 Tissue factor, thromboplastin, coagulation factor I

Myeloid cells, EC, Pit

Associates either with the CDw123, the CDw125, 120 or the CD16 molecule to form the appropriate functional receptor y chain of the receptors for IL-2 (see CD25 and 64 CDw122), IL-4 (see CD124), IL-7 (see CD127), IL-9, and IL-15. Mutation causes x-linked severe combined immunodeficiency Member of the TNF/NGF receptor family (see 48-50 CD27, CD30, CD40, CD95, CD120a, CD120b, CDw137). Costimulatory molecule of T cells. Involved in T-B and T-EC interactions by binding to the 0X40 ligand Belongs to the Ig and receptor tyrosine kinase 155 family (see CD115, CD117, CD140a, CD140b). Receptor for flt3 ligand. Important receptor/ligand system for hematopoietic cell proliferation and differentiation Member of the receptor tyrosine kinase family. 150, 35 The mature protein is organized as a disulfide-linked a//3 dimer, which is derived from a single chain pro RON. Involved in the regulation of production of blood cells, and in the development of epithelial tissue Member of the TNF/NGF receptor family (see 30 CD27, CD30, CD40, CD95, CD120a, CD120b, CD134). Receptor for 4-1BB ligand. Seems to be important for T cell survival The extracellular domain bears heparan sulfate 80-160 glycosamlnoglycans through which it binds both growth factors and extracellular matrix constituents. The cytoplasmic domain interacts with cytoskeletal components. Proposed to have roles in growth factor action, extracellular matrix adhesion and cytoskeletal organization that controls cell morphology Not fully characterized 220+250

Belongs to the Ig supergene and receptor 180

tyrosine kinase family (see CD115, CD117, CD135, CD140b). PDGF binding induces either homodimerization or heterodimerlzation with the CD140b molecule. Binds both PDGF-A and PDGF-B chains. Induces a mitogenic response Belongs to the Ig supergene and receptor 180

tyrosine kinase family (see CD115, CD117, CD135, CD 140a). PDGF binding induces either homodimerization or heterodimerization with the CD140a molecule. Binds PDGF-B chains. Induces a mitogenic response, actin reorganization and chemotaxis Receptor for thrombin. Involved in regulation of 100 coagulation

Related to the IFNa receptor and the CDw119 45 molecule. High-affinity receptor for factor VII, and it Is the essential cofactor for factor VII. Forms a ternary complex with factor VII and X to induce the extrinsic pathway of the coagulation cascade

Table 1 Continued
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