Cd40 And Its Ligand

Jacques Banchereau, Baylor Institute of Immunology Research, Dallas, Texas, USA Francine Briere, Schering-Plough, Laboratory for Immunological Research, Dardilly, France

Copyright © 1998 Elsevier Ltd. All Rights Reserved.

The CD40 antigen was identified in the mid-1980s from monoclonal antibodies that react with carcinomas and B cells and show costimulatory effects for B lymphocyte proliferation. In the early 1990s, the CD40 ligand (CD40-L) was identified on activated T cells and its genetic alteration was found to lead to the X-linked immunodeficiency referred to as the hyper IgM syndrome.

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