Cellular actions of lTB4 T lymphocytes

When LTB4 is added to human peripheral blood mononuclear leukocyte cultures stimulated with mitogenic lectins, an inhibition of the proliferative response can be observed. Similar findings are also observed for LTD4 and LTE4, and for 15-HETE in mice. A significant suppressor cell activity can indeed be generated at picomolar concentrations of LTB4.

Table 2 Expression of 5-LOX and FLAP in various cell populations

Cell population

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