Chemotaxis Of Macrophages And Monocytes

Peter C Wilkinson, Department of Immunology, University of Glasgow (Western Infirmary), Glasgow, UK

Copyright © 1998 Elsevier Ltd. All Rights Reserved.

The locomotor behavior of monocytes and macrophages, and their behavior in response to attractants, are as described in the article 'Chemotaxis'. Like neutrophils, they show chemotactic and chemokinetic responses under appropriate conditions and the direction of their locomotion also shows guidance in relation to aligned fibrous matrices. Monocytes and macrophages are quite strongly adherent cells and spread rapidly on substrata in vitro. As a consequence, their rate of locomotion on such substrata is slower than that of neutrophils, but is faster than that of fibroblasts which are even more adherent.

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