Clinical manifestations

Delayed-type hypersensitivity reactions are a prominent feature of several chronic diseases in humans, which for the most part are due to infectious agents, such as mycobacteria, protozoa and fungi. Important diseases include tuberculosis, leprosy, listeriosis, leishmaniasis, deep fungal infections (e.g. blastomycosis) and helminthic infections (e.g. schistosomiasis). These diseases are caused by pathogens which represent a persistent, chronic, antigenic stimulus. In such cases, protective immunity and delayed hypersensitivity often occur but are not always coincidental.

Instead of discussing these various DTH-related diseases, it may be more useful to describe under more general terms the various types of DTH reactions which may be encountered.

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