Cns

-----Infection route

Figure 1 Scrapie spread to the CNS.

Figure 1 Scrapie spread to the CNS.

likely to be the Sine gene product. There are several similar linkages of the PrP gene with susceptibility to GSS and other diseases in humans and susceptibility and resistance to natural and experimental scrapie in sheep. Disease does not develop in mice in which the PrP gene is ablated.

Other loci have minor effects on incubation period, including the major histocompatibility complex (MHC) of mouse (in the region of H2D) and sheep (various OLA loci, although the linkage is disputed).

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