Co

to u

Figure 1 Structure of IgE. Each of the immunoglobulin domains is represented by rectangles. Intrachain and interchain disulfide bridges are represented by S-S, and external glycosylation sites are shown as black circles. Also shown is the a-carbon backbone trace of the Ce3 and Ct4 domains, modeled on the homologous lgG1 structure, with the conserved internal (buried) carbohydrate between the two Ce3 domains.

gous to Asn297 in Cy2), which is buried between the two € chains in the model of IgE (Figure 1), and three additional sites (Asn265 in C€2 and Asn383 and Asn371 in Cf3), which should be exposed on the surface of IgE. Two of these, Asn371 and Asn383, however, do not appear to be fully occupied.

The crystal structure of IgG does not allow prediction of the structure of Ce2 or of its disposition with respect to Ce3, but X-ray scattering data on the IgE-Fc suggest that there is a sharp bend between these domains. This is consistent with evidence from fluorescence energy transfer experiments, which indicates that IgE is bent in solution and remains so when bound to its high-affinity receptor (Figure 2).

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment