Common Variable Immunodeficiency

Thomas A Selvaggi, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, Maryland, USA

Michael C Sneller, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

Common variable immunodeficiency (CVI) is a heterogeneous syndrome characterized by hypogammaglobulinemia and recurrent bacterial infections. This rare syndrome has an estimated prevalence ranging from 1:50000 to 1:200000. Although classified as a primary antibody deficiency syndrome, CVI represents a generalized state of immune dysregulation characterized by functional abnormalities of both T and B cells. Clinically, this is reflected in the susceptibility of these patients to a variety of conditions not easily explained on the basis of an isolated humoral immune defect.

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