Different T cell subsets have different roles in the various features of cell-mediated immunity, although these roles have not been fully characterized. In several experimental infections, the patterns of disease indicate preferential involvement of one or another T cell subset. Factors which influence the development of the several T lymphocyte subsets arc beginning to be understood, and the mechanisms that selectively regulate their responses have been partially defined.

See also: Antibody-dependent cellular cytotoxicity; Helper T lymphocytes; Contrasuppression; Cytokines; Cytotoxic T lymphocytes; Delayed-type hypersensitivity; Effector lymphocytes; Graft rejection; Graft-versus-host reaction; Mononuclear phagocyte system; Natural killer (NK) cells; Perforin; Suppressor T lymphocytes; T lymphocytes.

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